Urban pollutants impact mitochondrial function, contributing to premature skin aging and decreased resilience. mtBiolabs evaluates the effects of pollutants and the protective potential of cosmetic actives on mitochondrial bioenergetics, dynamics, and membrane integrity.
Exposure to urban pollutants—including particulate matter, PAHs, nitro-PAHs, PCBs, and chlorinated pesticides—directly affects mitochondrial function in skin cells. Our studies show that pollutants generate reactive oxygen species (ROS), impair mitochondrial bioenergetics, disrupt fusion-fission dynamics, and compromise membrane integrity.
The effects vary by donor age: fibroblasts from younger donors exhibit compensatory mitochondrial responses, whereas mature fibroblasts show reduced plasticity, leading to more pronounced bioenergetic and structural impairments.
Key mitochondrial effects identified in our studies:
These insights enable targeted testing of cosmetic ingredients that protect mitochondrial function and support anti-pollution claims.
What it is: Multiplexed assay measuring mitochondrial energy production and central metabolism in the same cell, used to identify anti-pollution actives.
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What it is: Module of Mitostream® technology analyzing fusion-fission balance, network mass, and density under pollutant exposure.
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What it is: Measures permeability transition of mitochondria as an indicator of pollutant-induced damage.
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What it is: Fibroblasts from donors of different ages and genders to test pollution impact and protection.
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What it is: Controlled exposure to urban atmospheric particulate matter containing PAHs, nitro-PAHs, PCBs, and chlorinated pesticides to mimic pollution.
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All our assays are fully customizable to meet your cosmetic testing needs.
Contact us to discuss your studyDiscover how our mitochondrial platforms support diverse cosmetic claims.
