mtBiolabs offers cardiac-focused mitochondrial assays to evaluate ATP production, mitochondrial dynamics, and cellular oxidative stress for cardioprotective drug assessment.
The mitochondrion is a complex organelle essential for energy transduction, ATP production, and multiple cellular signaling events. A finely tuned regulatory network controls the biogenesis, maintenance, and turnover of mitochondria. In the heart, this high-capacity mitochondrial system dynamically generates and consumes enormous amounts of ATP to support continuous pumping in response to changing energy demands1.
To sustain constant ATP production, malfunctioning mitochondria are continuously replaced by newly synthesized organelles through processes involving mitochondrial biogenesis, replication, and autophagy/mitophagy2,3. These processes are tightly regulated, with mitochondrial fusion and fission allowing the formation and remodeling of a reticulated mitochondrial network4.
Since mitochondria are responsible for ATP generation, any agent interfering with physiological mitochondrial function in the myocardium may deplete the cellular ATP pool, potentially leading to myocardial dysfunction.
Quantitative assessment of mitochondrial health is critical to evaluate potential cardioprotective compounds and detect unwanted cardiotoxic effects.
What it is: High-content analysis (HCA) to monitor mitochondrial DNA, mass, and biogenesis in cardiomyocytes.
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What it is: Multiplexed assessment of cardiac mitochondrial bioenergetics. Available in HTS/dose-response formats.
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What it is: Assays to profile ROS and antioxidant defense in cardiac cells, available in HTS/dose-response studies.
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All our assays are fully customizable to meet your needs.
Contact us to discuss your studyDiscover how our mitochondrial platforms support different therapeutic areas.
